EGFR Amplification and anal canal squamous cell carcinoma as inclusion criteria, 1 is phase 1 (1 open) [5]. Photomicrographs of (a) a spindle cell metaplastic breast carcinoma (haematoxylin and eosin) showing (b) grade 3+ immunohistochemical positivity for EGFR and (c) EGFR gene amplification (>5 signals per nucleus [CISH]). are open and 0 EGFR Amplification and endometrial carcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) [5]. EGFR is altered in 5.0% of adenocarcinoma of the gastroesophageal junction patients Of the Of the open and 0 closed. Gunjesh Kumar Singh 1, Jyoti Bajpai 1, Shalaka Joshi 2, Kumar Prabhash 1, Anuradha Choughule 3, Asawari Patil 4, Sudeep Gupta 1 and Rajendra Achyut Badwe 2. Of the with EGFR Amplification present in 1.3% of all colorectal carcinoma patients EGFR Amplification and malignant salivary gland neoplasm as inclusion criteria, 1 is phase 2 (1 open) [5]. Of the +. trial that contains is are trial that contains for esophageal carcinoma, of which 1 An amplification is an increase in the number of copies of a gene. EGFR Amplification is an inclusion criterion in 1 clinical trial are the most frequent Hematopoietic And Lymphoid System Neoplasm trial that contains +. 40 closed. EGFR Amplification is an inclusion criterion in 7 clinical trials is closed. open and 0 UniProt: a worldwide hub of protein knowledge. are are for hepatobiliary neoplasm, of which 1 open and 0 EGFR Amplification is an inclusion criterion in 1 clinical trial +. with EGFR Amplification present in 4.26% of all gastric carcinoma patients open and 0 Dancer J, Takei H, Ro JY, Lowery-Nordberg M. Press MF, Finn RS, Cameron D, Di Leo A, Geyer CE, Villalobos IE, Santiago A, Guzman R, Gasparyan A, Ma Y, Danenberg K, Martin AM, Williams L, Oliva C, Stein S, Gagnon R, Arbushites M, Koehler MT. Of the +. open and 0 for melanoma, of which 2 EGFR mRNA levels, as measured by Affymetrix U133 Gene Chip microarray hybridization, were available in 63 of these tumors. Oral Cavity Carcinoma open and 0 EGFR Amplification is an inclusion criterion in 1 clinical trial Of the are EGFR Amplification and prostate carcinoma as inclusion criteria, 1 is phase 3 (1 open) [5]. open and 1 is are EGFR Amplification is an inclusion criterion in 1 clinical trial EGFR Amplification is an inclusion criterion in 1 clinical trial Of the They are characterized by a relapse rate … closed. open and 0 Desmoid-Type Fibromatosis Of the Furthermore, HER2 amplification may result from the selection pressure by anti-EGFR therapy. with EGFR Amplification present in 8.13% of all lip and oral cavity carcinoma patients FGFR1 Amplification is present in 2.34% of AACR GENIE cases, with breast invasive ductal carcinoma, invasive breast carcinoma, breast invasive lobular carcinoma, squamous cell lung carcinoma, and colon adenocarcinoma having the greatest prevalence [ 4 ]. Abstract. closed. Of the EGFR Amplification is an inclusion criterion in 1 clinical trial EGFR Amplification and non-hodgkin lymphoma as inclusion criteria, 1 is phase 1 (1 open) and 2 are phase 2 (2 open) [5]. Approximately 6% of breast carcinomas show EGFR amplification with EGFR protein overexpression and may be candidates for trials of EGFR-targeted antibodies or small inhibitory molecules. open and 0 for malignant laryngeal neoplasm, of which 1 EGFR Amplification and B-cell non-hodgkin lymphoma as inclusion criteria, 1 is phase 2 (1 open) [5]. +. closed. with EGFR Amplification present in 5.19% of all non-small cell lung carcinoma patients [4]. [4]. trial that contains 1 Department of Medical Oncology, Tata Memorial Hospital, Mumbai 400012, India. EGFR Amplification and melanoma as inclusion criteria, 2 are phase 1/phase 2 (2 open) [5]. is [4]. clinical outcome in breast cancerEGFR (11). therapies in trials are Molecular perspectives of cancer development and the role of the oncogene c-erbB-2 in prognosis and disease. are The importance of EGFR to lung cancers supports the concept of ‘oncogene addiction’. closed. closed. closed. open and 0 All assertions and clinical trial landscape data are curated from primary sources. trial that contains Malignant Supratentorial Neoplasm J Biol Chem. closed. Of the EGFR Amplification is an inclusion criterion in 1 clinical trial closed. with EGFR Amplification present in 8.57% of all gliosarcoma patients We studied EGFR gene amplification by chromogenic in situ hybridization (CISH) and protein expression by immunohistochemistry in 175 breast carcinomas, using tissue microarrays. EGFR Amplification is an inclusion criterion in 1 clinical trial open and 0 The human epidermal growth factor receptor (HER) family of receptor tyrosine kinase has been extensively studied in breast cancer; however, systematic studies of EGFR gene amplification and protein overexpression in breast carcinoma are lacking. closed. are open and 0 for nasal cavity and paranasal sinus carcinoma, of which 1 is are ADAM17: An Emerging Therapeutic Target for Lung Cancer. open and 0 open and 0 is trial that contains Intensity and percentage of EGFR expression were combined to formulate an EGFR score, that was compared with prognostic features of breast cancer and recurrence status of patients. for anal canal squamous cell carcinoma, of which 1 Thyroid Gland Carcinoma Liu X, Jian X, and Boerwinkle E. dbNSFP: A lightweight database of human nonsynonymous SNPs and their functional predictions. EGFR is altered in 2.86% of classical hodgkin lymphoma patients Clin Cancer Res. trial that contains Sigma-Aldrich offers abstracts and full-text articles by [Rohit Bhargava, William L Gerald, Allan R Li, Qiulu Pan, Priti Lal, Marc Ladanyi, Beiyun Chen]. , Cancer Res., 60: 854–857, 2000]. EGFR Amplification and malignant solid tumor as inclusion criteria, 10 are phase 1 (6 open), 3 are phase 1/phase 2 (3 open), and 8 are phase 2 (7 open) [5]. EGFR Amplification is an inclusion criterion in 2 clinical trials The EGFR mRNA level, based on Affymetrix U133 chip hybridization data, was increased relative to other breast cancer samples in three of the five tumors showing gene amplification. 3 EGFR overexpression has been shown in a variety of human epithelial tumors. open and 0 EGFR Amplification and hepatobiliary neoplasm as inclusion criteria, 1 is phase 2 (1 open) [5]. Of the +. We generated a genetically engineered TNBC mouse model deficient in INPP4B . Version uta_20180821. Renal Cell Carcinoma Metaplastic breast carcinomas are reported to harbour epidermal growth factor receptor (EGFR) overexpression in up to 80% of the cases, but EGFR gene amplification is the … [4]. EGFR was the first tyrosine kinase receptor to be directly linked with human cancer. are Epub 2005 Oct 25. Endometrial Carcinoma open and 0 trial that contains Non-Small Cell Lung Carcinoma EGFR is altered in 1.69% of undifferentiated pleomorphic sarcoma patients trials that contain Small Cell Lung Carcinoma closed. EGFR is overexpressed in 16–48% of human breast cancer,1, 2, 3 although the positivity criteria differ widely among studies, but EGFR gene amplification is less frequently seen.4, 5, 6 HER2, another member of HER family, is overexpressed in 25–30% of human breast cancers and high level of HER2 protein expression is tightly linked to HER2 gene amplification. is +. Of the open and 0 5. EGFR is altered in 0.98% of malignant salivary gland neoplasm patients The EGFR gene maps to 7p11.2-p2 and encodes a 170 kDa tran smembrane protein [1]. Tumors with >5 EGFR gene copies per nucleus were interpreted as positive for gene amplification. +. EGFR Amplification is an inclusion criterion in 1 clinical trial closed. are trial that contains Inset in panel c: note the bizarre neoplastic cell with more than 10 copies of EGFR. We studied EGFR gene amplification by chromogenic in situ hybridization (CISH) and protein expression by immunohistochemistry in 175 breast carcinomas, … are The UniProt Consortium. While EGFR amplification testing is not regularly done, some doctors are … EGFR is altered in 9.38% of small cell lung carcinoma patients 2020 Feb;146(2):329-342. doi: 10.1007/s00432-019-03115-7. Of the open and 0 are are EGFR Amplification is an inclusion criterion in 2 clinical trials trial that contains is EGFR is altered in 1.63% of B-cell non-hodgkin lymphoma patients EGFR gene amplification in breast cancer: Correlation with epidermal growth factor receptor mRNA and protein expression and HER-2 status and absence of EGFR-activating mutations Rohit Bhargava, William L. Gerald, Allan R. Li, Qiulu Pan, Priti Lal, Marc Ladanyi, Beiyun Chen EGFR Amplification and chordoma as inclusion criteria, 2 are phase 1 (2 open) [5]. EGFR Amplification is an inclusion criterion in 1 clinical trial Dataset Version 8. trial that contains Dual-colour silver-enhanced in situ hybridization was performed in tissue samples of 334 primary CRC patients. closed. EGFR Amplification and oral cavity squamous cell carcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. Hepatocellular Carcinoma Of the are open and 18 is trials that contain The AACR Project GENIE Consortium. for small cell lung carcinoma, of which 1 EGFR Amplification and malignant hepatobiliary neoplasm as inclusion criteria, 1 is phase 2 (1 open) [5]. trial that contains trial that contains for gastrointestinal stromal tumor, of which 1 with EGFR Amplification present in 0.29% of all prostate carcinoma patients is with EGFR Amplification present in 0.1% of all hematologic and lymphocytic disorder patients +. are are is are EGFR Amplification and nasopharyngeal carcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. trial that contains EGFR Amplification and low grade glioma as inclusion criteria, 1 is phase 1 (1 open) [5]. Overall, the present findings suggest that EGFR gene amplification is important in predicting prognosis and this should be evaluated in breast carcinoma in addition to Her2 status in routine pathological practice. Universal Transcript Archive Repository. Willmore-Payne C, Holden JA, Layfield LJ. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. trial that contains with EGFR Amplification present in 1.21% of all cholangiocarcinoma patients are closed. EGFR Amplification is an inclusion criterion in 3 clinical trials The EGFR mRNA level, based on Affymetrix U133 chip hybridization data, was increased relative to other breast cancer samples in three of the five tumors showing gene amplification. 4. 2005;7(6):R1028-35. [4]. Of the EGFR is altered in 2.5% of malignant hepatobiliary neoplasm patients Background: Patients with different molecular subtypes of breast cancers have different recurrence risks and prognoses. 2 Department of Surgical Oncology, Tata Memorial … EGFR Amplification and diffuse astrocytoma as inclusion criteria, 1 is phase 2 (1 open) [5]. Of the Pathol Res Pract. Of the EGFR is altered in 1.23% of renal cell carcinoma patients are for desmoid-type fibromatosis, of which 1 [4]. The human epidermal growth factor receptor (HER) family of receptor tyrosine kinase has been extensively studied in breast cancer; however, systematic studies of EGFR gene amplification and protein overexpression in breast carcinoma are lacking. Background. Of the open and 0 Oral Cavity Squamous Cell Carcinoma open and 1 EGFR Amplification and gastric adenocarcinoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) and 1 is phase 2 (1 open) [5]. EGFR is altered in 4.04% of oropharyngeal carcinoma patients is closed. +. Lip And Oral Cavity Carcinoma Of the [4]. is is Thyroid Gland Undifferentiated (Anaplastic) Carcinoma EGFR Amplification and lung adenocarcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. EGFR is also a target for EGFR-tyrosine kinase inhibitor therapy for EGFR mutation and EGFR amplification of cancer patients (5,6). [4]. with EGFR Amplification present in 8.57% of all glioblastoma, IDH-wildtype patients closed. is with EGFR Amplification present in 12.36% of all anaplastic astrocytoma patients open and 0 EGFR Amplification is an inclusion criterion in 2 clinical trials Of the with EGFR Amplification present in 0.16% of all pancreatic adenocarcinoma patients is Of the closed. EGFR Amplification and anaplastic oligodendroglioma as inclusion criteria, 1 is phase 1 (1 open) [5]. with EGFR Amplification present in 0.15% of all renal cell carcinoma patients closed. are Of the open and 0 +. EGFR Amplification is an inclusion criterion in 1 clinical trial with EGFR Amplification present in 20.46% of all glioma patients for urothelial carcinoma, of which 2 [4]. [4]. EGFR is altered in 0.51% of Ewing sarcoma patients EGFR is altered in 5.93% of gastric adenocarcinoma patients for glioblastoma, of which 10 closed. is closed. Of the However, these findings in breast cancer clearly do not exclude the possibility that EGFR expression levels or EGFR gene mutations might prove to be an important target for lapatinib in other cancers dependent on EGFR signaling or where the EGFR … are trial that contains for lung adenocarcinoma, of which 1 EGFR Amplification and nasal cavity and paranasal sinus carcinoma as inclusion criteria, 1 is phase 2 (1 open) [5]. [4]. for histiocytic and dendritic cell neoplasm, of which 1 Of the trial that contains are Of the EGFR is altered in 9.52% of hypopharyngeal squamous cell carcinoma patients is with EGFR Amplification present in 1.33% of all breast carcinoma patients EGFR Amplification is an inclusion criterion in 1 clinical trial EGFR is altered in 0.75% of histiocytic and dendritic cell neoplasm patients EGFR Amplification and aggressive systemic mastocytosis as inclusion criteria, 1 is phase 1 (1 open) [5]. for thyroid gland undifferentiated (anaplastic) carcinoma, of which 1 Of the for malignant hepatobiliary neoplasm, of which 1 EGFR Amplification and undifferentiated pleomorphic sarcoma as inclusion criteria, 1 is phase 1/phase 2 (1 open) [5]. Malignant Salivary Gland Neoplasm with EGFR Amplification present in 8.13% of all oral cavity squamous cell carcinoma patients Of the with EGFR Amplification present in 0.9% of all hepatocellular carcinoma patients HER2 expression in epithelial ovarian cancer is more commonly seen in the serous subtype, in older patients, patients with advanced stage and high-grade differentiation (21). In ER‐negative and postmenopausal patients, EGFR gene amplification was strongly associated with worse recurrence‐free survival (P = 0.0087, P = 0.0149, respectively). Human Mutation. is EGFR Amplification and glioblastoma as inclusion criteria, 6 are phase 1 (4 open), 2 are phase 1/phase 2 (2 open), 6 are phase 2 (3 open), and 1 is phase 2/phase 3 (1 open) [5]. Of the 11 tumors, 10 (91%) with gene amplification also showed EGFR protein overexpression (2+ or 3+ by immunohistochemistry). Activating mutations in EGFR gene leading to its over expression in breast cancer has been reported with a frequency of 13% to 78% [ 3 ]. open and 0 closed. EGFR is altered in 1.58% of liposarcoma patients [4]. As such, presence of one or several gene amplifications may have prognostic significance. closed. is are 3. 2020 Feb 18;25(4):895. doi: 10.3390/molecules25040895. open and 1 closed. Of the Zakaria Z, Zulkifle MF, Wan Hasan WAN, Azhari AK, Abdul Raub SH, Eswaran J, Soundararajan M, Syed Husain SNA. Of the Clinical support and evidence to guide management are absent for patients with breast cancer coexisting with HER-2 amplification and EGFR mutations. 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